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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DDX3X
All Species:
14.85
Human Site:
S425
Identified Species:
23.33
UniProt:
O00571
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00571
NP_001347.3
662
73243
S425
K
V
V
W
V
E
E
S
D
K
R
S
F
L
L
Chimpanzee
Pan troglodytes
Q6GVM6
660
73172
L423
K
V
V
W
V
E
D
L
D
K
R
S
F
L
L
Rhesus Macaque
Macaca mulatta
XP_001095294
910
100218
S675
K
V
V
W
V
E
E
S
D
K
R
S
F
L
L
Dog
Lupus familis
XP_861268
662
73195
S425
K
V
V
W
V
E
E
S
D
K
R
S
F
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q62167
662
73083
I425
K
V
V
W
V
E
E
I
D
K
R
S
F
L
L
Rat
Rattus norvegicus
NP_001102328
659
72976
A423
K
V
V
W
V
E
E
A
D
K
R
S
F
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512924
651
71975
S411
K
V
V
W
V
E
E
S
D
K
R
S
F
L
L
Chicken
Gallus gallus
NP_001025971
651
72031
V414
I
T
Q
K
V
V
W
V
E
E
L
D
K
R
S
Frog
Xenopus laevis
P24346
697
77284
V460
S
E
N
I
T
Q
K
V
V
W
V
E
E
M
D
Zebra Danio
Brachydanio rerio
NP_571016
688
75828
E445
G
R
V
G
S
T
S
E
N
I
T
Q
K
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VHP0
798
85063
L543
E
P
D
K
R
S
Y
L
L
D
L
L
S
S
I
Honey Bee
Apis mellifera
XP_391829
701
78642
H463
K
I
V
W
V
E
E
H
D
K
R
S
Y
L
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9M2F9
646
69224
L389
D
S
D
K
R
S
H
L
M
D
L
L
H
A
Q
Baker's Yeast
Sacchar. cerevisiae
P24784
617
67899
T382
S
V
G
R
V
G
S
T
S
E
N
I
T
Q
R
Red Bread Mold
Neurospora crassa
Q9P6U9
688
72037
D437
Q
K
V
E
Y
V
E
D
I
D
K
R
S
V
L
Conservation
Percent
Protein Identity:
100
91.3
70.1
99.8
N.A.
98.6
95.3
N.A.
95.9
91.2
82.2
76.3
N.A.
51.7
58
N.A.
N.A.
Protein Similarity:
100
95.3
70.3
99.8
N.A.
99
97.1
N.A.
97.2
94.7
88
83.8
N.A.
63.4
70
N.A.
N.A.
P-Site Identity:
100
86.6
100
100
N.A.
93.3
93.3
N.A.
100
6.6
0
6.6
N.A.
0
80
N.A.
N.A.
P-Site Similarity:
100
93.3
100
100
N.A.
93.3
100
N.A.
100
20
20
26.6
N.A.
13.3
93.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
49.5
49.4
52
Protein Similarity:
N.A.
N.A.
N.A.
64.6
65.2
64.8
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
20
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
14
0
0
0
7
7
54
20
0
7
0
0
7
% D
% Glu:
7
7
0
7
0
54
54
7
7
14
0
7
7
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
47
0
0
% F
% Gly:
7
0
7
7
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
7
7
0
0
0
0
7
0
0
% H
% Ile:
7
7
0
7
0
0
0
7
7
7
0
7
0
0
7
% I
% Lys:
54
7
0
20
0
0
7
0
0
54
7
0
14
0
0
% K
% Leu:
0
0
0
0
0
0
0
20
7
0
20
14
0
54
60
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
0
7
0
% M
% Asn:
0
0
7
0
0
0
0
0
7
0
7
0
0
0
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
7
0
0
7
0
0
0
0
0
7
0
7
7
% Q
% Arg:
0
7
0
7
14
0
0
0
0
0
54
7
0
7
7
% R
% Ser:
14
7
0
0
7
14
14
27
7
0
0
54
14
7
7
% S
% Thr:
0
7
0
0
7
7
0
7
0
0
7
0
7
0
0
% T
% Val:
0
54
67
0
67
14
0
14
7
0
7
0
0
14
7
% V
% Trp:
0
0
0
54
0
0
7
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
7
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _